Comparison of non sedating antihistamines

We scoured the research and analyzed the 37 most available pills, sprays, liquids, and drops at mainstream pharmacies to find the best symptom-relieving (and least zombifying) defense during allergy season.

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The question, is it necessary to spend the extra money?

" These newer products, which include Allegra, Zyrtec, and Claritin, generally cost between 10 to 20 times as much as the older, "first-generation" products.

It flags these as invaders and goes on the attack, releasing histamine, which in turn triggers the itchy eyes, runny nose, and congestion we all associate with the start of spring.

We talked to a trio of allergists and they all agreed: a spritz of corticosteroid up the nose is the best way to beat seasonal allergies — but oral antihistamines and, in the short term, eye drops make great backups.

We started with a list of 37 allergy medications sold at mainstream pharmacies (Walgreens, Target, Duane Reade, etc.), then talked to immunologists and read academic scientific journals to find which ones work best.

Everything we looked at is over-the-counter — no prescription necessary.

Interactions with other drugs are more common with first-generation antihistamines compared with second-generation antihistamines.

Second generation antihistamines were developed in the 1980s and are much less sedating than first-generation antihistamines.

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